Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump
Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul.A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this read more receptor.It is generally assumed that the antagonism leads to induction of cytochrome P450 7A1 (CYP